Mitochondrial Quality Control in COPD and IPF
Hiromichi Hara * ID , Kazuyoshi Kuwano and Jun Araya
Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine,
Tokyo 105-8461, Japan; kkuwano@jikei.ac.jp (K.K.); araya@jikei.ac.jp (J.A.)Correspondence: hirohara@jikei.ac.jp; Tel.: +81-3-3433-1111; Fax: +81-3-3433-1020
Published: 24 July 2018
Abstract: Mitochondria play important roles in the maintenance of intracellular homeostasis; hence,
the quality control of mitochondria is crucial for cell fate determination. Mitochondria dynamics and
mitochondria-specific autophagy, known as mitophagy, are two main quality control systems in cells.
Mitochondria fuse to increase energy production in response to stress, and damaged mitochondria are
segregated by fission and degraded by mitophagy. Once these systems are disrupted, dysfunctional
mitochondria with decreased adenosine triphosphate (ATP) production and increased reactive oxygen
species (ROS) production accumulate, affecting cell fate. Recently, increasing evidence suggests that
the dysregulation of mitochondria quality control is pathogenic in several age-related diseases.
In this review, we outlined the role of mitochondria quality control systems in the pathogenesis
of age-associated lung diseases, chronic obstructive pulmonary disease (COPD) and idiopathic
pulmonary fibrosis (IPF).
Keywords: mitochondria; mitochondria dynamics; mitophagy; chronic obstructive pulmonary
disease (COPD); idiopathic pulmonary fibrosis (IPF)
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Citations
MDPI and ACS Style
Hara, H.; Kuwano, K.; Araya, J. Mitochondrial Quality Control in COPD and IPF. Cells 2018, 7, 86. https://doi.org/10.3390/cells7080086
AMA Style
Hara H, Kuwano K, Araya J. Mitochondrial Quality Control in COPD and IPF. Cells. 2018; 7(8):86. https://doi.org/10.3390/cells7080086
Chicago/Turabian Style
Hara, Hiromichi, Kazuyoshi Kuwano, and Jun Araya. 2018. “Mitochondrial Quality Control in COPD and IPF” Cells 7, no. 8: 86. https://doi.org/10.3390/cells7080086
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