Pulmonary fibrosis, or lung scarring, makes the lungs stiffer and less able to work normally. This can make breathing more difficult and reduce the amount of oxygen available to the body. Signs and symptoms may include: What should you do?If you have been struggling with your breathing or have a persistent cough, make an appointment […]
Category: Fibrotic remodeling
Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling
Abstract The mitochondrial calcium uniporter (MCU) regulates metabolic reprogramming in lung macrophages and the progression of pulmonary fibrosis. Fibrosis progression is associated with apoptosis resistance in lung macrophages; however, the mechanism(s) by which apoptosis resistance occurs is poorly understood. Here, we found a marked increase in mitochondrial B-cell lymphoma-2 (Bcl-2) in lung macrophages from subjects […]