Abstract The mitochondrial calcium uniporter (MCU) regulates metabolic reprogramming in lung macrophages and the progression of pulmonary fibrosis. Fibrosis progression is associated with apoptosis resistance in lung macrophages; however, the mechanism(s) by which apoptosis resistance occurs is poorly understood. Here, we found a marked increase in mitochondrial B-cell lymphoma-2 (Bcl-2) in lung macrophages from subjects […]
Tag: Idiopathic pulmonary fibrosis
Mitochondrial Quality Control in COPD and IPF
Mitochondrial Quality Control in COPD and IPF Hiromichi Hara * ID , Kazuyoshi Kuwano and Jun Araya Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine,Tokyo 105-8461, Japan; kkuwano@jikei.ac.jp (K.K.); araya@jikei.ac.jp (J.A.)Correspondence: hirohara@jikei.ac.jp; Tel.: +81-3-3433-1111; Fax: +81-3-3433-1020Published: 24 July 2018 Abstract: Mitochondria play important roles in the maintenance of intracellular […]