September is Pulmonary Fibrosis (PF) Awareness Month. During this month, health charities, research institutes and support groups around the world provide information about Pulmonary Fibrosis. Pulmonary fibrosis is a progressive, incurable disease that affects the tissues in the lungs resulting in lung scarring. Overtime, this leads to a decline in lung function. Sufferers will notice […]
Tag: Pulmonary Fibrosis Research and Education Hub
Type 1 invariant natural killer T cells in chronic inflammation and tissue fibrosis
Citation: Kumar V, Hertz M, Agro A and Byrne AJ (2023) Type 1 invariant natural killer T cells in chronic inflammation and tissue fibrosis. Front. Immunol. 14:1260503. doi: 10.3389/fimmu.2023.1260503 Chronic tissue inflammation often results in fibrosis characterized by the accumulation of extracellular matrix components remodeling normal tissue architecture and function. Recent studies have suggested common immune mechanisms despite […]
September is Pulmonary Fibrosis (PF) Awareness Month
September is Pulmonary Fibrosis (PF) Awareness Month. During this month, health charities, research institutes and support groups around the world provide information about Pulmonary Fibrosis. Pulmonary fibrosis is a progressive, incurable disease that affects the tissues in the lungs resulting in lung scarring. Overtime, this leads to a decline in lung function. Sufferers will notice […]
Exercise training in idiopathic pulmonary fibrosis: is it of benefit?
Abstract Exercise is a well-documented safe and effective intervention for prevention and rehabilitation of chronic diseases. Idiopathic pulmonary fibrosis (IPF) is a chronic deadly lung disease associated with severe signs and symptoms, exercise intolerance, diminished quality of life and poor prognosis. In the short term, supervised exercise training programmes have demonstrated clinical benefits in improving […]
Evaluation for clinical benefit of metformin in patients with idiopathic pulmonary fibrosisand type 2 diabetes mellitus: a national claims‑based cohort analysis
Abstract BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with high morbidity and limited treatment options. Type 2 diabetes mellitus (T2DM) is a common comorbid illness among patients with IPF and is often treated with metformin, the first-line agent in the management of T2DM. There is growing evidence demonstrating metformin’s anti-fibrotic properties; however, […]
Plasticity towards Rigidity: A Macrophage Conundrum in
Pulmonary Fibrosis
Abstract: Idiopathic pulmonary fibrosis (IPF) is a progressive, chronic, and ultimately fatal diffuse parenchymal lung disease. The molecular mechanisms of fibrosis in IPF patients are not fully understood and there is a lack of effective treatments. For decades, different types of drugs such as immunosuppressants and antioxidants have been tested, usually with unsuccessful results. Although […]
Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling
Abstract The mitochondrial calcium uniporter (MCU) regulates metabolic reprogramming in lung macrophages and the progression of pulmonary fibrosis. Fibrosis progression is associated with apoptosis resistance in lung macrophages; however, the mechanism(s) by which apoptosis resistance occurs is poorly understood. Here, we found a marked increase in mitochondrial B-cell lymphoma-2 (Bcl-2) in lung macrophages from subjects […]
Mitochondrial Quality Control in COPD and IPF
Mitochondrial Quality Control in COPD and IPF Hiromichi Hara * ID , Kazuyoshi Kuwano and Jun Araya Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine,Tokyo 105-8461, Japan; kkuwano@jikei.ac.jp (K.K.); araya@jikei.ac.jp (J.A.)Correspondence: hirohara@jikei.ac.jp; Tel.: +81-3-3433-1111; Fax: +81-3-3433-1020Published: 24 July 2018 Abstract: Mitochondria play important roles in the maintenance of intracellular […]
Idiopathic Pulmonary Fibrosis (IPF): An Overview
Idiopathic Pulmonary Fibrosis (IPF): An Overview Shaney L. Barratt 1,2,*, Andrew Creamer 1, Conal Hayton 3 and Nazia Chaudhuri 3 1 Bristol Interstitial Lung Disease Service, North Bristol NHS Trust, Bristol BS10 5NB, UK;andrew.creamer@nbt.nhs.uk2 Academic Respiratory Unit, University of Bristol, Bristol BS16 1QY, UK3 North West Interstitial Lung Disease Unit, Manchester University NHS Foundation Trust, […]
Pulmonary Fibrosis Research and Education Hub
Welcome to the Pulmonary Fibrosis Research and Education Hub which is run and maintained by the Natonal Wellbeing Service Ltd.